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KMID : 0894320080110010058
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Dongguk Journal of the Institute of Oriental Medicine
2008 Volume.11 No. 1 p.58 ~ p.65
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Effect of BHT-C extract on the infarction in cerebral ischemic rats
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Kim Sung-Yun
Park Yong-Ki
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Abstract
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Objectives : BHT has been commonly used to treatment of brain disorders in Oriental clinic in Korea. The purpose of this study was to determine the inhibitory effect of modified BHT-C extract on the transient forcal cerebral ischemia in rats.
Method : We prepared ischemic rats by the transient middle cerebral artery occlution(MCAO; 90 min occlusion and 144 h reperfusion) in rat brains. BHT-C extract (100 and 200 mg/kg, i.p.) was administered every day after the onset of MCAO until 6 day.
Result : BHT-C extract increased survival rate of ischemic rats compared with vehicle-treated rats. BHT-C extract treated rats (100 and 200 mg/kg) were shown a significant reduction in infarct volume compared with vehicle-treated rats.
Conclusions : These results suggest that BHT-C extract may contribute to its protective effects in brain ischemia through the reduction of brain infarction.
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KEYWORD
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Brain ischemia, BHT, MCAO rats, infarction
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